EMTRICITABINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H10FN3O3S
Molecular Weight	247.247
Optical Activity	( - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of EMTRICITABINE

Structure Search

SMILES

NC1=NC(=O)N(C=C1F)[C@@H]2CS[C@H](CO)O2

InChI

InChIKey=XQSPYNMVSIKCOC-NTSWFWBYSA-N

InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C8H10FN3O3S
Molecular Weight	247.247
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:56:53 UTC 2023` Edited by `admin` on `Fri Dec 15 15:56:53 UTC 2023`
Record UNII	G70B4ETF4S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EMTRICITABINE

Official Name

English

524W91

Code

English

EMTRICITABINE, (-)-

Common Name

English

STRIBILD COMPONENT EMTRICITABINE

Brand Name

English

EMTRICITABINE COMPONENT OF STRIBILD

Brand Name

English

EVIPLERA COMPONENT EMTRICITABINE

Brand Name

English

DESCOVY COMPONENT EMTRICITABINE

Common Name

English

5-FLUORO-1-(2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL)CYTOSINE (2R,5S)

Common Name

English

EMTRICITABINE COMPONENT OF DESCOVY

Common Name

English

EMTRICITABINE COMPONENT OF TRUVADA

Brand Name

English

EMTRICITABINE [USP-RS]

Common Name

English

EMTRICITABINE COMPONENT OF GENVOYA

Brand Name

English

DESCOVY COMPONENT OF EMTRICITABINE

Common Name

English

TRUVADA COMPONENT EMTRICITABINE

Brand Name

English

2(1H)-PYRIMIDINONE, 4-AMINO-5-FLUORO-1-((2R,5S)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL)-

Systematic Name

English

EMTRIVA

Brand Name

English

ATRIPLA COMPONENT EMTRICITABINE

Common Name

English

(-)-EMTRICITABINE

Common Name

English

FTC

Common Name

English

ODEFSEY COMPONENT EMTRICITABINE

Brand Name

English

EMTRICITABINE [MART.]

Common Name

English

COVIRACIL

Brand Name

English

EMTRICITABINE [MI]

Common Name

English

Emtricitabine [WHO-DD]

Common Name

English

EMTRICITABINE [EMA EPAR]

Common Name

English

EMTRICITABINE COMPONENT OF ODEFSEY

Brand Name

English

EMTRICITABINE [VANDF]

Common Name

English

EMTRICITABINE [ORANGE BOOK]

Common Name

English

5-Fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

Systematic Name

English

EMTRICITABINE COMPONENT OF EVIPLERA

Brand Name

English

EMTRICITABINE [JAN]

Common Name

English

524-W-91

Code

English

EMTRICITABINE [HSDB]

Common Name

English

EMTRICITABINE [USAN]

Common Name

English

FTC-(-)

Common Name

English

EMTRICITABINUM [WHO-IP LATIN]

Common Name

English

EMTRICITABINE COMPONENT OF ATRIPLA

Common Name

English

EMTRICITABINE [WHO-IP]

Common Name

English

(-)-FTC

Common Name

English

BW-524W91

Code

English

emtricitabine [INN]

Common Name

English

(2R-CIS)-4-AMINO-5-FLUORO-1-(2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL)-2(1H)-PYRIMIDINONE

Systematic Name

English

Classification Tree Code System Code

WHO-ESSENTIAL MEDICINES LIST

6.4.2.3 (FTC/TEN)

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

6.4.2.3 (EFV/FTC/TEN)

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

EMA ASSESSMENT REPORTS

TRUVADA (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

EMA ASSESSMENT REPORTS

EMTRIVA (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AF09

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-VATC

QJ05AR09

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

EMA ASSESSMENT REPORTS

DESCOVY (AUTHORIZED: HIV INFECTIONS )

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

NDF-RT

N0000175459

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

NCI_THESAURUS

C1557

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AR18

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

NDF-RT

N0000175462

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

NDF-RT

N0000175459

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

FDA ORPHAN DRUG

569716

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

NDF-RT

N0000009947

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-VATC

QJ05AR06

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

EMA ASSESSMENT REPORTS

STRIBILD (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

EMA ASSESSMENT REPORTS

EVIPLERA (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

LIVERTOX

NBK548261

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-VATC

QJ05AR08

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

EMA ASSESSMENT REPORTS

ATRIPLA (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AR09

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

EMA ASSESSMENT REPORTS

GENVOYA (AUTHORIZED: HIV INFECTIONS)

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-VATC

QJ05AF09

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AR06

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AR03

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

FDA ORPHAN DRUG

559316

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

NCI_THESAURUS

C97452

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

EU-Orphan Drug

EU/3/14/1420

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AR19

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-VATC

QJ05AR03

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AR20

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

6.4.2.1

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AR17

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

NDF-RT

N0000175459

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

WHO-ATC

J05AR08

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

Code System Code Type Description

HSDB

7337

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

DRUG BANK

DB00879

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

EPA CompTox

DTXSID0040129

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

PUBCHEM

60877

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

SMS_ID

100000091720

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

NCI_THESAURUS

C47509

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

EVMPD

SUB01882MIG

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

INN

7822

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

DAILYMED

G70B4ETF4S

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

MERCK INDEX

m4892

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

Merck Index

MESH

C122114

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

USAN

KK-33

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

ChEMBL

CHEMBL885

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

FDA UNII

G70B4ETF4S

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

CHEBI

31536

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

EMTRICITABINE

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

Description: White to almost white, crystalline powder. Solubility: Freely soluble in methanol R and water R, practically insoluble in dichloromethane R. Category: Antiretroviral (Nucleoside Reverse Transcriptase Inhibitor). Storage: Emtricitabine should be kept in a tightly closed container. Additional information: Emtricitabine may exhibit polymorphism.

DRUG CENTRAL

1003

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

CAS

143491-57-0

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

RS_ITEM_NUM

1235106

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

LACTMED

Emtricitabine

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

WIKIPEDIA

EMTRICITABINE

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

RXCUI

276237

Created by admin on Fri Dec 15 15:56:54 UTC 2023 , Edited by admin on Fri Dec 15 15:56:54 UTC 2023

PRIMARY

RxNorm

Related Record Type Details


					859A956UY8

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1

TARGET ORGANISM->INHIBITOR

Amount:


					4AF605U6JN

MRP-2

TRANSPORTER -> INHIBITOR


					1YV0492L5Z

MRP-3

TRANSPORTER -> INHIBITOR


					A3Z87NSO0U

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 POLYMERASE

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					ULS8902U4O

EMTRICITABINE, (±)-

RACEMATE -> ENANTIOMER

Amount:


					9PDN1V466A

EMTRICITABINE, (+)-

ENANTIOMER -> ENANTIOMER

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

Related Record Type Details


					A05BWI66K0

EMTRICITABINE-2'-O-GLUCURONIDE

METABOLITE -> PARENT

Comments:

About 4% of dose

Interaction Type:

MINOR

Qualification:

URINE

Amount:


					Y00K47B026

EMTRICITABINE SULFOXIDE

METABOLITE -> PARENT

Comments:

9% of dose

Interaction Type:

MAJOR

Qualification:

URINE

Amount:


					842MLG4LPF

EMTRICITABINE 5'-TRIPHOSPHATE

METABOLITE ACTIVE -> PARENT

Amount:

Related Record Type Details


					U3P01618RT

IMPURITY -> PARENT


					LXO1HF9QGI

EMTRICITABINE S-OXIDE (S)-EPIMER

IMPURITY -> PARENT

Amount:


					RQ3X62U8VM

4-AMINO-5-FLUORO-1-((2S,4S)-2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL)PYRIMIDIN-2(1H)-ONE

IMPURITY -> PARENT


					9PDN1V466A

EMTRICITABINE, (+)-

IMPURITY -> PARENT

Amount:


					2T8Q726O95

IMPURITY -> PARENT

Amount:


					3F3F7L71JJ

4-AMINO-5-FLUORO-1-((2RS,5RS)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL)-2(1H)-PYRIMIDINONE

IMPURITY -> PARENT

Amount:


					7D832RLM83

EMTRICITABINE 5-FLUOROURACIL

IMPURITY -> PARENT

Amount:


					D83282DT06

IMPURITY -> PARENT


					61557K3S8B

EMTRICITABINE CARBOXYLIC ACID

IMPURITY -> PARENT

Amount:


					79RVV445GQ

EMTRICITABINE MENTHYL ESTER

IMPURITY -> PARENT

Amount:


					7N3B9DY4NJ

1,1'-(DISULFANEDIYLBIS(METHYLENE-(2R,5S)-1,3-OXATHIOLANE-2,5-DIYL))BIS(4-AMINO-5-FLUOROPYRIMIDIN-2(1H)-ONE)

IMPURITY -> PARENT

Amount:


					9D66R2JWY4

EMTRICITABINE S-OXIDE (R)-EPIMER

IMPURITY -> PARENT

Amount:

Related Record Type Details


					G70B4ETF4S

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Tmax	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC