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Details

Stereochemistry ABSOLUTE
Molecular Formula C27H29F3O6S
Molecular Weight 538.576
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUTICASONE FUROATE

SMILES

[H][C@@]12C[C@@H](C)[C@](OC(=O)C3=CC=CO3)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]4(F)[C@@]2([H])C[C@H](F)C5=CC(=O)C=C[C@]45C

InChI

InChIKey=XTULMSXFIHGYFS-VLSRWLAYSA-N
InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1

HIDE SMILES / InChI
Molecular Formula C27H29F3O6S
Molecular Weight 538.576
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 9 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:26:57 UTC 2023
Edited
by admin
on Fri Dec 15 16:26:57 UTC 2023
Record UNII
JS86977WNV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FLUTICASONE FUROATE
EMA EPAR   INN   JAN   MART.   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
TRELEGY ELLIPTA COMPONENT FLUTICASONE FUROATE
Brand Name English
FLUTICASONE FUROATE [VANDF]
Common Name English
Fluticasone Furoate [WHO-DD]
Common Name English
ALLERMIST
Brand Name English
GSK 685 698
Code English
FLUTICASONE FUROATE [JAN]
Common Name English
FLUTICASONE FUROATE [MART.]
Common Name English
GSK685968
Code English
(6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-6,9-DIFLUORO-17-(((FLUORO-METHYL)THIO)CARBONYL)-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL 2-FURANCARBOXYLATE
Systematic Name English
FLUTICASONE FUROATE COMPONENT OF TRELEGY ELLIPTA
Brand Name English
ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID, 6,9-DIFLUORO-17-((2-FURANYLCARBONYL)OXY)-11-HYDROXY-16-METHYL-3-OXO-, S-(FLUOROMETHYL) ESTER, (6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-
Common Name English
GW685698X
Code English
FURAMIST
Brand Name English
GSK-685968
Code English
FLUTICASONE FUROATE COMPONENT OF ARNUITY ELLIPTA
Brand Name English
FLUTICASONE FUROATE [EMA EPAR]
Common Name English
(6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-6,9-DIFLUORO-17-(((FLUOROMETHYL)THIO)CARBONYL)-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL-2-FURANCARBOXYLATE
Common Name English
BREO ELLIPTA COMPONENT FLUTICASONE FUROATE
Brand Name English
(6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-6,9-DIFLUORO-17-(((FLUOROMETHYL)THIO)CARBONYL)-11-HYDROXY-16-METHYL-3-OXOANDROSTA-1,4-DIEN-17-YL 2-FUROATE
Common Name English
fluticasone furoate [INN]
Common Name English
ENNHALE
Brand Name English
FLUTICASONE FUROATE COMPONENT OF BREO ELLIPTA
Brand Name English
FLUTICASONE FUROATE [MI]
Common Name English
FLUTICASONE FUROATE [ORANGE BOOK]
Common Name English
FLUTICASONE FUROATE [USAN]
Common Name English
ARNUITY ELLIPTA COMPONENT FLUTICASONE FUROATE
Brand Name English
AVAMYS
Brand Name English
VERAMYST
Brand Name English
6α,9-Difluoro-17-[[(fluoromethyl)sulfanyl]carbonyl]-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-dien-17α-yl furan-2-carboxylate
Common Name English
GW-685698X
Code English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS RELVAR ELLIPTA (AUTHORIZED: PULMONARY DISEASE, CHRONIC OBSTRUCTIVE)
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
WHO-VATC QR01AD12
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
WHO-ATC R01AD12
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
WHO-ATC R03AL08
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
EMA ASSESSMENT REPORTS ALISADE (WITHDRAWN)
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
EMA ASSESSMENT REPORTS REVINITY ELLIPTA (AUTHORIZED: ASTHMA)
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
WHO-ATC R03AL08
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
NCI_THESAURUS C521
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
WHO-ATC R03AK10
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
WHO-ATC R03BA09
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
EMA ASSESSMENT REPORTS AVAMYS (AUTHORIZED)
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
WHO-VATC QR03AK10
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
Code System Code Type Description
RXCUI
705022
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID401024827
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
INN
8521
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
DAILYMED
JS86977WNV
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
NCI_THESAURUS
C77003
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
DRUG CENTRAL
4554
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
WIKIPEDIA
FLUTICASONE FUROATE
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
SMS_ID
100000092736
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
CAS
397864-44-7
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
PUBCHEM
9854489
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
DRUG BANK
DB08906
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
USAN
SS-41
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
FDA UNII
JS86977WNV
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
EVMPD
SUB26593
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
MERCK INDEX
m11711
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
ChEMBL
CHEMBL1676
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
MESH
C523187
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
CHEBI
74899
Created by admin on Fri Dec 15 16:26:57 UTC 2023 , Edited by admin on Fri Dec 15 16:26:57 UTC 2023
PRIMARY
Related Record Type Details
GLUCOCORTICOID RECEPTOR
TARGET -> AGONIST
enhanced-affinity glucocorticoid
AGONIST
Structure of FLUTICASONE
PARENT -> DERIVATIVE
Related Record Type Details
Structure of GSK-728921A
METABOLITE -> PARENT
PLASMA
Structure of GW-694301X
METABOLITE INACTIVE -> PARENT
MAJOR
PLASMA
Structure of GSK-728920A
METABOLITE -> PARENT
FECAL; PLASMA
Structure of GW-694301X
METABOLITE -> PARENT
FECAL
Related Record Type Details
Structure of FLUTICASONE FUROATE
ACTIVE MOIETY
Page 31 of 152
FECAL; PLASMA
Structure of FLUTICASONE FUROATE
ACTIVE MOIETY
Scientific Literature
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC
ORAL BIOAVAILABILITY PHARMACOKINETIC INTRANASAL
PHARMACOKINETIC
ORAL
PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC ORAL INHALATION
PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
Route of Elimination PHARMACOKINETIC RENAL, IV
PHARMACOKINETIC
RENAL, ORAL
PHARMACOKINETIC
FECAL, ORAL
PHARMACOKINETIC
PROTEIN BINDING PHARMACOKINETIC
NIH
NCATS
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