LOXAPINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18ClN3O
Molecular Weight	327.808
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LOXAPINE

Structure Search

SMILES

CN1CCN(CC1)C2=NC3=C(OC4=C2C=C(Cl)C=C4)C=CC=C3

InChI

InChIKey=XJGVXQDUIWGIRW-UHFFFAOYSA-N

InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H18ClN3O
Molecular Weight	327.808
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:30:04 UTC 2023` Edited by `admin` on `Fri Dec 15 17:30:04 UTC 2023`
Record UNII	LER583670J
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LOXAPINE

Official Name

English

SUM-3170

Code

English

SUM 3170

Code

English

CL 62,362

Code

English

2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)DIBENZ(B,F)(1,4)OXAZEPINE

Systematic Name

English

loxapine [INN]

Common Name

English

ADASUVE

Brand Name

English

LOXAPINE [USAN]

Common Name

English

DIBENZ(B,F)(1,4)OXAZEPINE, 2-CHLORO-11-(4-METHYL-1-PIPERAZINYL)-

Systematic Name

English

CL-62362

Code

English

LOXAPINE [MI]

Common Name

English

LOXAPINE [VANDF]

Common Name

English

Loxapine [WHO-DD]

Common Name

English

LOXAPINE [ORANGE BOOK]

Common Name

English

LOXAPINE [HSDB]

Common Name

English

LOXAPINE [MART.]

Common Name

English

Classification Tree Code System Code

LIVERTOX

NBK548875

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

NCI_THESAURUS

C29710

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

EMA ASSESSMENT REPORTS

ADASUVE (AUTHORIZED: SCHIZOPHRENIA)

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

WHO-VATC

QN05AH01

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

WHO-ATC

N05AH01

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

EMA ASSESSMENT REPORTS

ADASUVE (AUTHORIZED: BIPOLAR DISORDER)

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

Code System Code Type Description

WIKIPEDIA

LOXAPINE

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

DAILYMED

LER583670J

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

CAS

1977-10-2

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

RXCUI

6475

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

RxNorm

PUBCHEM

3964

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

ECHA (EC/EINECS)

217-835-3

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

HSDB

3111

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

IUPHAR

205

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

DRUG BANK

DB00408

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

DRUG CENTRAL

1613

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

EPA CompTox

DTXSID7023229

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

FDA UNII

LER583670J

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

INN

2610

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

NCI_THESAURUS

C61816

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

MERCK INDEX

m6915

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

Merck Index

MESH

D008152

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

ChEMBL

CHEMBL831

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

SMS_ID

100000092266

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

CHEBI

50841

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

LACTMED

Loxapine

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

EVMPD

SUB08607MIG

Created by admin on Fri Dec 15 17:30:05 UTC 2023 , Edited by admin on Fri Dec 15 17:30:05 UTC 2023

PRIMARY

Related Record Type Details


					X59SG0MRYU

LOXAPINE SUCCINATE

SALT/SOLVATE -> PARENT


					NQI5D806LC

5-HYDROXYTRYPTAMINE RECEPTOR 2A

TARGET -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					376MYL4MAL

LOXAPINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					LR0F81F33L

ALDEHYDE OXIDASE

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:

Related Record Type Details


					9Z11F654NR

7-HYDROXYAMOXAPINE

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

URINE


					6WRG4I7D8N

7-HYDROXYLOXAPINE

METABOLITE -> PARENT


					0Q6HMM3XRC

8-HYDROXYLOXAPINE

METABOLITE -> PARENT


					6WRG4I7D8N

7-HYDROXYLOXAPINE

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA; URINE


					R63VQ857OT

AMOXAPINE

METABOLITE -> PARENT

85EE9A1E8B

LOXAPINE N-OXIDE

METABOLITE -> PARENT

Interaction Type:

MINOR

Qualification:

PLASMA


					6WRG4I7D8N

7-HYDROXYLOXAPINE

METABOLITE -> PARENT


					0D4T741I48

8-HYDROXYAMOXAPINE

METABOLITE -> PARENT

Qualification:

PLASMA; URINE


					0Q6HMM3XRC

8-HYDROXYLOXAPINE

METABOLITE ACTIVE -> PARENT

Interaction Type:

MAJOR

Qualification:

PLASMA; URINE

85EE9A1E8B

LOXAPINE N-OXIDE

METABOLITE -> PARENT

Comments:

Mediator: flavanoid monoamine oxidases

Related Record Type Details


					LER583670J

LOXAPINE

ACTIVE MOIETY