AMOXAPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16ClN3O
Molecular Weight	313.781
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

ClC1=CC2=C(OC3=C(C=CC=C3)N=C2N4CCNCC4)C=C1

InChI

InChIKey=QWGDMFLQWFTERH-UHFFFAOYSA-N

InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2

HIDE SMILES / InChI

Molecular Formula	C17H16ClN3O
Molecular Weight	313.781
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical
Record UNII	R63VQ857OT
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

AMOXAPINE

Official Name

English

AMOXAPINE [USP MONOGRAPH]

Common Name

English

AMOXAPINE [VANDF]

Common Name

English

2-CHLORO-11-(1-PIPERAZINYL)DIBENZ(B,F)(1,4)OXAZEPINE

Systematic Name

English

NSC-759559

Code

English

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Classification Tree

Code System

Code

Non-selective monoamine reuptake inhibitors

WHO-VATC

QN06AA17

Established Pharmacologic Class

NDF-RT

N0000175752

Non-selective monoamine reuptake inhibitors

WHO-ATC

N06AA17

Antidepressant

LIVERTOX

NBK548520

Antidepressant Agent

NCI_THESAURUS

C94727

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Code System

Code

Type

Description

DRUG CENTRAL

191

PRIMARY

EVMPD

SUB05479MIG

PRIMARY

LACTMED

Amoxapine

PRIMARY

RXCUI

722

PRIMARY

RxNorm

FDA UNII

R63VQ857OT

PRIMARY

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					SKQ3P7VSJ7

3-CHLORO-11-(PIPERAZIN-1-YL)DIBENZO(B,F)(1,4)OXAZEPINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

[<0.15] PERCENT PEAK AREA (limits)


					S21Y22XI1D

1,4-BIS(2-CHLORODIBENZO(B,F)(1,4)OXAZEPINE-11-YL)PIPERAZINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

[<0.1] PERCENT PEAK AREA (limits)


					XTG2E7M36O

2-CHLORODIBENZO(B,F)-1,4-OXAZEPIN-11-ONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

[<0.15] PERCENT PEAK AREA (limits)


					CA590E7L17

N-(2-(4-CHLOROPHENOXY)PHENYL)PIPERAZINE-1-CARBOXAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

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USP

Amount:

[<0.1] PERCENT PEAK AREA (limits)


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2-(4-CHLOROPHENOXY)ANILINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

[<0.1] PERCENT PEAK AREA (limits)

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					R63VQ857OT

AMOXAPINE

ACTIVE MOIETY

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Name	Property Type	Amount
Biological Half-life	PHARMACOKINETIC	8 hours (average)

Volume of Distribution	PHARMACOKINETIC	[0.9 to 1.2] Liters/Kilogram (average)