FLUTICASONE PROPIONATE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H31F3O5S
Molecular Weight	500.571
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of FLUTICASONE PROPIONATE

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@](OC(=O)CC)(C(=O)SCF)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=WMWTYOKRWGGJOA-CENSZEJFSA-N

InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H31F3O5S
Molecular Weight	500.571
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:13:48 UTC 2023` Edited by `admin` on `Fri Dec 15 15:13:48 UTC 2023`
Record UNII	O2GMZ0LF5W
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLUTICASONE PROPIONATE

Official Name

English

FLUTICASONE PROPIONATE [ORANGE BOOK]

Common Name

English

ADVAIR COMPONENT FLUTICASONE PROPIONATE

Brand Name

English

FLUTICASONE PROPIONATE [USP MONOGRAPH]

Common Name

English

CUTIVATE

Brand Name

English

S-FLUOROMETHYL 6.ALPHA., 9.ALPHA.-DIFLUORO-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-17.ALPHA.-PROPIONYLOXYANDROSTA-1,4-DIENE-17.BETA-. CARBOTHIOATE

Common Name

English

FLIXOTIDE

Brand Name

English

FLUTICASONE PROPIONATE [EP MONOGRAPH]

Common Name

English

FLUTICASONE PROPIONATE COMPONENT OF DYMISTA

Common Name

English

ARMONAIR RESPICLICK

Brand Name

English

LIPO-102 COMPONENT FLUTICASONE PROPIONATE

Common Name

English

FLUTICASONE PROPIONATE [JAN]

Common Name

English

FLOVENT

Code

English

CCI18781

Code

English

FLUTICASONE PROPIONATE [USP-RS]

Common Name

English

PF-00241939

Code

English

FLUTICASONE PROPIONATE [MART.]

Common Name

English

AIRDUO RESPICLICK COMPONENT FLUTICASONE PROPIONATE

Brand Name

English

NSC-759889

Code

English

DYMISTA COMPONENT FLUTICASONE PROPIONATE

Common Name

English

FLUTICASONE PROPIONATE [USAN]

Common Name

English

CCI-18781

Code

English

XHANCE

Brand Name

English

ADVAIR HFA COMPONENT FLUTICASONE PROPIONATE

Common Name

English

Fluticasone propionate [WHO-DD]

Common Name

English

ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID, 6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)-, (6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-S-(FLUOROMETHYL) ESTER

Common Name

English

FLUTICASONE PROPIONATE COMPONENT OF ADVAIR

Brand Name

English

FLUTICASONE PROPIONATE COMPONENT OF AIRDUO RESPICLICK

Brand Name

English

FLUTICASONE PROPIONATE [MI]

Common Name

English

FLUTICASONE PROPIONATE COMPONENT OF ADVAIR HFA

Common Name

English

FLUTICASONE-17-PROPIONATE

Common Name

English

FLUTICASONE PROPIONATE [VANDF]

Common Name

English

FLONASE

Brand Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

273208

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

EU-Orphan Drug

EU/3/16/1815

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

FDA ORPHAN DRUG

319410

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

FDA ORPHAN DRUG

499815

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

NCI_THESAURUS

C521

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

Code System Code Type Description

PUBCHEM

444036

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

EVMPD

SUB02241MIG

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

MERCK INDEX

m5510

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

Merck Index

WIKIPEDIA

FLUTICASONE PROPIONATE

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

ChEMBL

CHEMBL1473

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

DAILYMED

O2GMZ0LF5W

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

SMS_ID

100000092718

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

DRUG CENTRAL

1225

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

NSC

759889

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

FDA UNII

O2GMZ0LF5W

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

DRUG BANK

DB00588

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

USAN

W-145

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

CAS

80474-14-2

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

RS_ITEM_NUM

1285873

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

RXCUI

50121

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

RxNorm

IUPHAR

7080

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

NCI_THESAURUS

C29061

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

EPA CompTox

DTXSID8045511

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

CHEBI

31441

Created by admin on Fri Dec 15 15:13:48 UTC 2023 , Edited by admin on Fri Dec 15 15:13:48 UTC 2023

PRIMARY

Related Record Type Details


					FZW85LW99M

GLUCOCORTICOID RECEPTOR

TARGET -> AGONIST

Amount:


					O2GMZ0LF5W

FLUTICASONE PROPIONATE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

USP

Amount:


					O2GMZ0LF5W

FLUTICASONE PROPIONATE

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (HPLC)

Qualification:

EP

Amount:


					CUT2W21N7U

PARENT -> DERIVATIVE

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Amount:

Related Record Type Details


					TP537C010A

FLUTICASONE PROPIONATE-17.BETA.-CARBOXYLIC ACID

METABOLITE INACTIVE -> PARENT

Amount:

Related Record Type Details


					J2CJB114C9

6.ALPHA.,9-DIFLUORO-17-(((FLUOROMETHYL)SULFANYL)CARBONYL)-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXOANDROST-4-EN-17.ALPHA.-YL PROPANOATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					ETY5QGU5JY

17-[[[[(6α,11β,16α,17α)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl]carbonyl]dithio]carbonyl]-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)Androsta-1,4-dien-3-one

IMPURITY -> PARENT

Amount:


					YXC5X4NLK5

(6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID

IMPURITY -> PARENT

Amount:


					3MMC9W0495

TICABESONE PROPIONATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					EP20877CWZ

6.ALPHA.,9.ALPHA.-DIFLUORO-11.BETA.-HYDROXY-16.ALPHA.-METHYL-2',3,4'-TRIOXO-17.ALPHA.-SPIRO(ANDROSTA-1,4-DIENE-17,5'-(1,3)OXATHIOLANE)

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					1V165RFB9Y

6.ALPHA.,9-DIFLUORO-17-(((FLUOROMETHYL)SULFANYL)CARBONYL)-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIEN-17.ALPHA.-YL 6.ALPHA.,9-DIFLUORO-11.BETA.,17-DIHYDROXY-16.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIENE-17.BETA.-CARBOXYLATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					EUS9FD6209

6ALPHA, 9ALPHA-DIFLUORO-11BETA,17ALPHA-DIHYDROXY-16ALPHA-METHYL-3-OXOANDROSTA-1,4-DIENE-17BETA-CARBOXYLIC ACID

IMPURITY -> PARENT

Amount:


					TP537C010A

FLUTICASONE PROPIONATE-17.BETA.-CARBOXYLIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					3MMC9W0495

TICABESONE PROPIONATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					1V165RFB9Y

6.ALPHA.,9-DIFLUORO-17-(((FLUOROMETHYL)SULFANYL)CARBONYL)-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIEN-17.ALPHA.-YL 6.ALPHA.,9-DIFLUORO-11.BETA.,17-DIHYDROXY-16.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIENE-17.BETA.-CARBOXYLATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					33UEQ4E893

FLUTICASONE SULFENIC ACID PROPIONATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					XO35CTG0YC

6.ALPHA.,9-DIFLUORO-17-(((FLUOROMETHYL)SULFANYL)CARBONYL)-16.ALPHA.-METHYL-3,11-DIOXOANDROSTA-1,4-DIEN-17.ALPHA.-YL PROPANOATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					1BIA3ZKX8V

FLUTICASONE ACETATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					1BIA3ZKX8V

FLUTICASONE ACETATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					33UEQ4E893

FLUTICASONE SULFENIC ACID PROPIONATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					78EC7RJ4C2

FLUOROMETHYL (6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOXYLATE

IMPURITY -> PARENT

Amount:


					CC8AR5RHS2

6.ALPHA.,9-DIFLUORO-17-((FLUOROMETHOXY)CARBONOTHIOYL)-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIEN-17.ALPHA.-YL PROPANOATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					718MRE2B9T

DESFLUOROMETHYL FLUTICASONE PROPIONATE DISULFIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					9RM5TT5FXU

17,17'-(DITHIODICARBONOTHIOYL)BIS(6,9-DIFLUORO-11-HYDROXY-16-METHYL-17-(1-OXOPROPOXY)-ANDROSTA-1,4-DIEN-3-ONE

IMPURITY -> PARENT

Amount:


					NV97EC5KJW

6.ALPHA.-CHLORO-9-FLUORO-17-(((FLUOROMETHYL)SULFANYL)CARBONYL)-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIEN-17.ALPHA.-YL PROPANOATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					KP2FZY6867

S-(BROMOMETHYL) (6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOATE

IMPURITY -> PARENT

Amount:

Related Record Type Details


					O2GMZ0LF5W

FLUTICASONE PROPIONATE

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

PROTEIN BINDING (PLASMA PROTEIN)	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				TOPICAL PHARMACOKINETIC

MAXIMUM TOLERATED DOSE	TOXICITY				FLOVENT HFA INHALATION AEROSOL RESPICLICK INHLATION POWDER XHANCE (TM) FLOVENT DISKUS INHALATION POWDER

ORAL BIOAVAILABILITY	PHARMACOKINETIC				INHALATION, AEROSOL: ALMOST COMPLETE INTRANASAL PHARMACOKINETIC

Route of Elimination	PHARMACOKINETIC				RENAL PHARMACOKINETIC