DIAZEPAM

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H13ClN2O
Molecular Weight	284.74
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DIAZEPAM

Structure Search

SMILES

CN1C2=C(C=C(Cl)C=C2)C(=NCC1=O)C3=CC=CC=C3

InChI

InChIKey=AAOVKJBEBIDNHE-UHFFFAOYSA-N

InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

HIDE SMILES / InChI

Molecular Formula	C16H13ClN2O
Molecular Weight	284.74
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:05:32 UTC 2023` Edited by `admin` on `Sat Dec 16 17:05:32 UTC 2023`
Record UNII	Q3JTX2Q7TU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DIAZEPAM

Official Name

English

VALTOCO

Brand Name

English

RO 5-2807

Code

English

DIAZEPAM [VANDF]

Common Name

English

ANSIOLISINA

Common Name

English

DIAZEPAM CIV

Common Name

English

VALIUM

Brand Name

English

LA-III

Code

English

DIAZEPAM [GREEN BOOK]

Common Name

English

DIZAC

Brand Name

English

SERVIZEPAM

Common Name

English

DIAZEPAM [IARC]

Common Name

English

RO-5-2807

Code

English

DIAZEPAM [USAN]

Common Name

English

DIASTAT

Brand Name

English

NSC-77518

Code

English

LA III

Code

English

2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-

Systematic Name

English

NSC-169897

Code

English

DIAZEPAM [ORANGE BOOK]

Common Name

English

RO-52807

Code

English

7-CHLORO-1-METHYL-5-PHENYL-3H-1,4-BENZODIAZEPIN-2(1H)-ONE

Systematic Name

English

DIAZEPAM [HSDB]

Common Name

English

WY-3467

Code

English

METHYL DIAZEPINONE

Systematic Name

English

CENTRAZEPAM

Common Name

English

Q-PAM

Brand Name

English

7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-2H-1,4-BENZODIAZEPINE-2-ONE

Systematic Name

English

VALRELEASE

Brand Name

English

DIAZEPAM [MART.]

Common Name

English

DIACEPIN

Common Name

English

Diazepam [WHO-DD]

Common Name

English

DIAZEPAM [MI]

Common Name

English

diazepam [INN]

Common Name

English

DIAZEPAM [USP MONOGRAPH]

Common Name

English

DIAZEPAM [JAN]

Common Name

English

NRL-1

Code

English

DIAZEPAM [EP MONOGRAPH]

Common Name

English

DIAZEPAM CIV [USP-RS]

Common Name

English

7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one

Systematic Name

English

TRANQUASE

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000007542

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

FDA ORPHAN DRUG

384112

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

EPA PESTICIDE CODE

600069

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

FDA ORPHAN DRUG

334911

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

FDA ORPHAN DRUG

518316

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

8.4

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

LIVERTOX

NBK548352

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

WHO-VATC

QN05BA01

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

FDA ORPHAN DRUG

543516

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

FDA ORPHAN DRUG

638118

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

24.3

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

FDA ORPHAN DRUG

382512

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

WHO-ATC

N05BA01

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

05

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

DEA NO.

2765

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

NCI_THESAURUS

C1012

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

FDA ORPHAN DRUG

61591

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

NDF-RT

N0000175694

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

Code System Code Type Description

RS_ITEM_NUM

1185008

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

MERCK INDEX

m4267

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

Merck Index

NSC

169897

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

RXCUI

3322

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

RxNorm

MESH

D003975

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

HSDB

3057

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

LACTMED

Diazepam

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

DRUG BANK

DB00829

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

EPA CompTox

DTXSID4020406

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

DRUG CENTRAL

852

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

WIKIPEDIA

DIAZEPAM

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

EVMPD

SUB07069MIG

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

IUPHAR

3364

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

FDA UNII

Q3JTX2Q7TU

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

NCI_THESAURUS

C28982

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

INN

1295

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

CAS

439-14-5

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

PUBCHEM

3016

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

ChEMBL

CHEMBL12

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

CHEBI

49575

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

ECHA (EC/EINECS)

207-122-5

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

SMS_ID

100000092362

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

DAILYMED

Q3JTX2Q7TU

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

NSC

77518

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

WHO INTERNATIONAL PHARMACOPEIA

DIAZEPAM

Created by admin on Sat Dec 16 17:05:34 UTC 2023 , Edited by admin on Sat Dec 16 17:05:34 UTC 2023

PRIMARY

Description: A white or almost white, crystalline powder; odourless or almost odourless. Solubility: Very slightly soluble in water; soluble in ethanol (~750 g/l) TS. Category: Tranquillizer. Storage: Diazepam should be kept in a well-closed container, protected from light. Definition: Diazepam contains not less than 99.0% and not more than 101.0% of C16H13ClN2O, calculated with reference to the dried substance.

Related Record Type Details


					081I12ZA58

CYTOCHROME P450 2C19

METABOLIC ENZYME -> SUBSTRATE


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					6JD21U639H

DIAZEPAM HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					805SU96HKF

CYTOCHROME P450 3A5

METABOLIC ENZYME -> SUBSTRATE

Related Record Type Details


					65NK71K78P

AVIZAFONE

PRODRUG -> METABOLITE ACTIVE


					CHB1QD2QSS

TEMAZEPAM

METABOLITE ACTIVE -> PARENT


					67220MCM01

METABOLITE ACTIVE -> PARENT


					D4GD5770PI

5-CHLORO-2-METHYLAMINOBENZOPHENONE

METABOLITE -> PARENT

Amount:


					6GOW6DWN2A

OXAZEPAM

METABOLITE ACTIVE -> PARENT


					67220MCM01

METABOLITE TOXIC -> PARENT

Comments:

Metabolite produces adverse autonomic nervous symptoms in man.

Related Record Type Details


					451IV63H4H

N-(2-BENZOYL-4-CHLOROPHENYL)-2-CHLORO-N-METHYLACETAMIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					67220MCM01

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					5W5807YWL0

7-CHLORO-2-METHOXY-5-PHENYL-3H-1,4-BENZODIAZEPINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					D4GD5770PI

5-CHLORO-2-METHYLAMINOBENZOPHENONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					WQ6317625G

3-AMINO-6-CHLORO-1-METHYL-4-PHENYLCARBOSTYRIL

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					NKP63GON0W

1-METHYL-4-PHENYL-6-CHLORO-2-QUINAZOLINONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					Q3JTX2Q7TU

DIAZEPAM

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
pKa	CHEMICAL
Volume of Distribution	PHARMACOKINETIC
Tmax	PHARMACOKINETIC				IV: 8 minutes IM: 1.31 hours (SYRINGE) IM: 1.47 hours (AUTOINJECTOR) EFFECT OF FOOD: DELAYED Tmax RECTAL GEL: 1.5 hours

PROTEIN BINDING	PHARMACOKINETIC
Biological Half-life	PHARMACOKINETIC				IV: 15-21 HOURS (CHILD 2-12 YEARS) IV: 40-50 HOURS (INFANT AND TODDLER 1 MONTH TO 2 YEARS) IV: 18-20 HOURS (ADOLESCENT 12-16 YEARS) IV: 50-95 HOURS (NEONATE, BIRTH UP TO 1 MONTH) IV: ABOUT 100 HOURS (ELDERLY 95 YEARS) IV: ABOUT 15 HOURS (YOUNG ADULT 18 YEARS) PREMATURE INFANTS, 28-34 WEEKS GESTATIONAL AGE AND 8-81 DAYS POSTPARTUM: 54 HOURS DESMETHYLDIAZEPAM: UP TO 100 HOURS GERIATRICS: INCREASES BY ABOUT 1 HOUR FOR EACH YEAR OF AGE BEGINNING WITH A HALF-LIFE OF 20 HOURS AT 20 YEARS OF AGE CHILDREN 3-8 YEARS: 18 HOURS FULL TERM INFANTS: 30 HOURS
MAXIMUM TOLERATED DOSE	TOXICITY				SEDATION, ENDOSCOPIC PROCEDURE: 20 mg IV IMMEDIATELY PRIOR TO PROCEDURE SEVERE, RECURRENT SEIZURE: 30 mg/dose IV

ORAL BIOAVAILABILITY	PHARMACOKINETIC

BIOAVAILABILTY	PHARMACOKINETIC