CHLORPROMAZINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H19ClN2S
Molecular Weight	318.864
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CHLORPROMAZINE

Structure Search

SMILES

CN(C)CCCN1C2=C(SC3=C1C=C(Cl)C=C3)C=CC=C2

InChI

InChIKey=ZPEIMTDSQAKGNT-UHFFFAOYSA-N

InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C17H19ClN2S
Molecular Weight	318.864
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:15:14 UTC 2023` Edited by `admin` on `Fri Dec 15 15:15:14 UTC 2023`
Record UNII	U42B7VYA4P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CHLORPROMAZINE

Official Name

English

CHLORPROMAZINUM

Common Name

English

ESMIND

Common Name

English

CHLORPROMAZINE [MART.]

Common Name

English

2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine

Systematic Name

English

CHLORPROMAZINUM [HPUS]

Common Name

English

Chlorpromazine [WHO-DD]

Common Name

English

NSC-226514

Code

English

SANOPRON

Common Name

English

CHLORPROMAZINE [VANDF]

Common Name

English

chlorpromazine [INN]

Common Name

English

J2.794D

Code

English

SKF-2601A

Code

English

CHLORPROMAZINE [HSDB]

Common Name

English

CHLORPROMAZINE [USP MONOGRAPH]

Common Name

English

NSC-167745

Code

English

PROPAPHENIN

Common Name

English

10H-PHENOTHIAZINE-10-PROPANAMINE, 2-CHLORO-N,N-DIMETHYL-

Systematic Name

English

CPZ

Common Name

English

3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)-N,N-DIMETHYLPROPAN-1-AMINE

Systematic Name

English

LARGACTILOTHIAZINE

Common Name

English

WINTERMIN

Common Name

English

FENACTIL

Common Name

English

CHLORPROMAZINE [ORANGE BOOK]

Common Name

English

THORAZINE

Brand Name

English

NOVOMAZINA

Common Name

English

CHLORPROMAZINE [MI]

Common Name

English

AMINAZINE

Common Name

English

Classification Tree Code System Code

WHO-ATC

N05AA01

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

NDF-RT

N0000175746

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

NDF-RT

N0000007544

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

WHO-VATC

QN05AA01

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

NDF-RT

N0000007544

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

NCI_THESAURUS

C29710

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

24.1

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

NDF-RT

N0000007544

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

NCI_THESAURUS

C740

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

LIVERTOX

NBK548793

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

Code System Code Type Description

DAILYMED

U42B7VYA4P

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

ChEMBL

CHEMBL71

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

CAS

50-53-3

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

DRUG BANK

DB00477

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

IUPHAR

83

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

DRUG CENTRAL

621

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

HSDB

3033

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

NCI_THESAURUS

C367

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-045-8

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

EVMPD

SUB06208MIG

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

CHEBI

3647

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

EPA CompTox

DTXSID0022808

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

PUBCHEM

2726

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

INN

183

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

MERCK INDEX

m3461

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

Merck Index

NSC

167745

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

SMS_ID

100000081894

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

LACTMED

Chlorpromazine

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

RXCUI

2403

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

RxNorm

FDA UNII

U42B7VYA4P

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

EVMPD

SUB01255MIG

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

MESH

D002746

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

NSC

226514

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

WIKIPEDIA

CHLORPROMAZINE

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

CHEBI

3649

Created by admin on Fri Dec 15 15:15:15 UTC 2023 , Edited by admin on Fri Dec 15 15:15:15 UTC 2023

PRIMARY

Related Record Type Details


					657G38Q829

CHLORPROMAZINE HIBENZATE

SALT/SOLVATE -> PARENT


					31V857ZRPY

ALPHA-1-ACID GLYCOPROTEIN

BINDING PROTEIN->LIGAND

Comments:

chlorpromazine displayed an approximately 1:1 [drug:AGP] binding stoichiometry; DETERMINED BY ITC

Interaction Type:

BINDING

Qualification:

Kd

Amount:


					Q98X428KKM

CHLORPROMAZINE MALEATE

SALT/SOLVATE -> PARENT


					85RG9X8ZHE

CHLORPROMAZINE PAMOATE

SALT/SOLVATE -> PARENT


					Q7A4S7HOP4

ALPHA-1B ADRENERGIC RECEPTOR

TARGET -> INHIBITOR


					UKK18ES9TF

5-HYDROXYTRYPTAMINE RECEPTOR 1A

TARGET -> INHIBITOR


					28XBT591QG

HISTAMINE H1 RECEPTOR

TARGET -> INHIBITOR


					LR0F81F33L

ALDEHYDE OXIDASE

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


					3T7136LE8K

ALPHA-1A ADRENERGIC RECEPTOR

TARGET -> INHIBITOR


					9WP59609J6

CHLORPROMAZINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					NQI5D806LC

5-HYDROXYTRYPTAMINE RECEPTOR 2A

TARGET -> INHIBITOR


					54202V7DRJ

D(1A) DOPAMINE RECEPTOR

TARGET -> INHIBITOR


					19GBD6T9L7

D(2) DOPAMINE RECEPTOR

TARGET -> INHIBITOR


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					46995AIA65

CHLORPROMAZINE ASCORBATE

SALT/SOLVATE -> PARENT


					8E4LAA4357

CYTOCHROME P450 2D6

METABOLIC ENZYME -> SUBSTRATE

Comments:

Metabolizing reaction by CYP2D6: N-demethylation Pharmacological action: Phenothiazine antipsychotic

Interaction Type:

SUBSTRATE

Qualification:

Unidentified

Related Record Type Details


					X7VB4M8YKQ

2-CHLORO-10-(2-CARBOXYETHYL)PHENOTHIAZINE

METABOLITE -> PARENT


					95H3AO2301

2-CHLOROPHENOTHIAZINE

METABOLITE -> PARENT

Amount:


					53QHA9YP6R

MONODEMETHYLCHLORPROMAZINE SULFOXIDE

METABOLITE -> PARENT


					SE77HEK68D

10H-PHENOTHIAZIN-3-OL, 8-CHLORO-10-(3-(DIMETHYLAMINO)PROPYL)-, 5-OXIDE

METABOLITE -> PARENT


					WC539X9GR2

7-HYDROXYCHLORPROMAZINE SULFOXIDE GLUCURONIDE

METABOLITE -> PARENT


					MRD4MC89GP

METABOLITE -> PARENT


					UWS2TA46B8

DI-N-DEMETHYL-CHLORPROMAZINE

METABOLITE -> PARENT


					BDS415V3UI

7-HYDROXYNORCHLORPROMAZINE

METABOLITE -> PARENT


					O1G7LW1I5H

DEMETHYLCHLORPROMAZINE

METABOLITE ACTIVE -> PARENT

Amount:


					Y66J555ZRY

7-HYDROXYMONODESMETHYLCHLORPROMAZINE SULFOXIDE

METABOLITE -> PARENT


					5PF9UV6E3U

7-OME-CPZ

METABOLITE -> PARENT


					EG9M28FXV6

7-HYDROXYDIDESMETHYLCHLORPROMAZINE

METABOLITE -> PARENT


					016U10PN9N

METABOLITE -> PARENT

Amount:


					554G882EZP

METABOLITE -> PARENT


					6148VKM65V

CHLORPROMAZINE SULFONE

METABOLITE -> PARENT


					SW9NBC54AQ

7-HYDROXYDESDIMETHYLCHLORPROMAZINE SULFOXIDE

METABOLITE -> PARENT


					1MQC1JTJ7S

2-CHLORO-7-HYDROXYPHENOTHIAZINE

METABOLITE -> PARENT


					CV9SY9L2WY

7-HYDROXYCHLORPROMAZINE GLUCURONIDE

METABOLITE -> PARENT


					FF5BHM455R

7-HYDROXYDIDEMETHYLCHLORPROMAZINE GLUCURONIDE

METABOLITE -> PARENT


					JZ7MCA8TJH

DIDEMETHYLCHLORPROMAZINE SULFOXIDE

METABOLITE -> PARENT


					P0X9L6UVP0

7-HYDROXYCHLORPROMAZINE

METABOLITE -> PARENT

Related Record Type Details


					U42B7VYA4P

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC