PRAZOSIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H21N5O4
Molecular Weight	383.4011
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PRAZOSIN

Structure Search

SMILES

COC1=CC2=NC(=NC(N)=C2C=C1OC)N3CCN(CC3)C(=O)C4=CC=CO4

InChI

InChIKey=IENZQIKPVFGBNW-UHFFFAOYSA-N

InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)

HIDE SMILES / InChI

Molecular Formula	C19H21N5O4
Molecular Weight	383.4011
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:15:36 UTC 2023` Edited by `admin` on `Fri Dec 15 15:15:36 UTC 2023`
Record UNII	XM03YJ541D
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PRAZOSIN

Official Name

English

prazosin [INN]

Common Name

English

1-(4-AMINO-6,7-DIMETHOXYQUINAZOLIN-2-YL)-4-(FURAN-2-YLCARBONYL)PIPERAZINE

Systematic Name

English

CP-122991

Code

English

TERAZOSIN HYDROCHLORIDE DIHYDRATE IMPURITY K [EP IMPURITY]

Common Name

English

PRAZOSIN [VANDF]

Common Name

English

PRAZOSIN [MI]

Common Name

English

Prazosin [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29713

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

WHO-VATC

QC02LE01

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

NCI_THESAURUS

C270

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

WHO-ATC

C02CA01

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

WHO-ATC

C02LE01

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

NDF-RT

N0000175553

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

NDF-RT

N0000000099

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

WHO-VATC

QC02CA01

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

LIVERTOX

NBK548699

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

Code System Code Type Description

CAS

19216-56-9

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

CHEBI

8364

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

PUBCHEM

4893

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

IUPHAR

503

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

ECHA (EC/EINECS)

242-885-8

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

MESH

D011224

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

SMS_ID

100000081402

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

FDA UNII

XM03YJ541D

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

DAILYMED

XM03YJ541D

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

WIKIPEDIA

PRAZOSIN

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

NCI_THESAURUS

C767

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

ChEMBL

CHEMBL2

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

RXCUI

8629

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

RxNorm

EPA CompTox

DTXSID4049082

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

MERCK INDEX

m9108

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

Merck Index

DRUG BANK

DB00457

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

INN

2593

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

LACTMED

Prazosin

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

DRUG CENTRAL

4209

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

EVMPD

SUB10011MIG

Created by admin on Fri Dec 15 15:15:36 UTC 2023 , Edited by admin on Fri Dec 15 15:15:36 UTC 2023

PRIMARY

Related Record Type Details


					3T7136LE8K

ALPHA-1A ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					4007E25Z4Z

OCT-3

TRANSPORTER -> INHIBITOR


					93V99BB37L

ALPHA-2B ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Comments:

Binding Assay

Qualification:

IC50

Amount:


					6QZ7XLY9SJ

LABELED -> NON-LABELED

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					P5O3A2DHB2

ALPHA-1D ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Comments:

Binding Assay

Qualification:

IC50

Amount:


					Q7A4S7HOP4

ALPHA-1B ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Amount:


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR


					Q7A4S7HOP4

ALPHA-1B ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					P5O3A2DHB2

ALPHA-1D ADRENERGIC RECEPTOR

TARGET -> INHIBITOR

Amount:


					X0Z7454B90

PRAZOSIN HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					5DUS6A8SSC

PRAZOSIN N-GLUCURONIDE

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:


					X8C5VTG33W

2,4-DIAMINO-6,7-DIMETHOXYQUINAZOLINE

METABOLITE -> PARENT

Comments:

IN VIVO

Amount:


					VSQ01PZ7IR

1-(4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-1-PIPERAZINYL)-5-HYDROXY-1,2-PENTANEDIONE

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:


					H91B0F6RR5

(4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-3,4-DIHYDRO-1(2H)-PYRAZINYL)-2-FURANYLMETHANONE

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:


					1IK5UK05RI

6-DESMETHYL PRAZOSIN

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:


					XEB020ANM7

PRAZOSIN 6O-GLUCURONIDE

METABOLITE TOXIC -> PARENT

Comments:

IN VITRO

Amount:


					1X8JI3451K

1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)PIPERAZINE

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:


					QEH894MW4S

PRAZOSIN 7O-GLUCURONIDE

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:


					8Z0QOM4NUS

5-(4-(4-AMINO-6,7-DIMETHOXY-QUINAZOLIN-2-YL)-PIPERAZIN-1-YL)-4,5-DIOXO-PENTANOIC ACID

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:


					VKZ5L84Q39

7-DESMETHYL PRAZOSIN

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:


					B2DNL9OUD2

4-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-1-(2-FURANYLCARBONYL)-2,3,4,5-TETRAHYDROPYRAZINIUM

METABOLITE -> PARENT

Comments:

IN VITRO

Amount:

Related Record Type Details


					D32S14F082

TERAZOSIN HYDROCHLORIDE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					XM03YJ541D

PRAZOSIN

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Tmax	PHARMACOKINETIC				ORAL ADMINISTRATION

Biological Half-life	PHARMACOKINETIC