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Development Status
Investigational
128
US Approved Rx
67
Possibly Marketed Outside US
21
Other
12
Designated
1
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Primary Target
Vascular endothelial growth factor receptor 2
33
Epidermal growth factor receptor erbB1
25
Platelet-derived growth factor receptor beta
25
Stem cell growth factor receptor
25
Receptor protein-tyrosine kinase erbB-2
18
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Highest Phase
Approved
63
Phase II
61
Phase III
44
Phase I
16
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Approval Year
Unknown
157
2018
10
2017
8
2019
6
2013
5
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Condition
Non-small cell lung cancer
36
Breast cancer
27
Ovarian cancer
18
Solid tumors
18
Rheumatoid arthritis
17
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Treatment Modality
Primary
185
Palliative
6
Secondary
4
Preventing
3
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CNS Activity
CNS Penetrant
58
CNS Active
22
CNS Non-penetrant
9
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Originator
Pfizer
13
Novartis
10
AstraZeneca
9
Array BioPharma
7
Eli Lilly
6
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Substance Class
Chemical
227
Protein
3
Mixture
1
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INN Stem
Tyrosine-kinase inhibitors(-tinib)
1
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Code System
CAS
231
FDA UNII
231
NCI_THESAURUS
231
PUBCHEM
226
SMS_ID
203
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Protein Type
MONOCLONAL ANTIBODY
1
MONOCLONAL ANTIBODY CONJUGATE
1
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ATC Level 1
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
34
ALIMENTARY TRACT AND METABOLISM
1
BLOOD AND BLOOD FORMING ORGANS
1
DERMATOLOGICALS
1
MUSCULO-SKELETAL SYSTEM
1
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ATC Level 2
ANTINEOPLASTIC AGENTS
30
IMMUNOSUPPRESSANTS
3
ANTIHEMORRHAGICS
1
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
1
BILE AND LIVER THERAPY
1
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ATC Level 3
OTHER ANTINEOPLASTIC AGENTS
30
IMMUNOSUPPRESSANTS
3
BILE THERAPY
1
HORMONE ANTAGONISTS AND RELATED AGENTS
1
OTHER DERMATOLOGICAL PREPARATIONS
1
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ATC Level 4
Protein kinase inhibitors
30
Selective immunosuppressants
2
Agents for dermatitis, excluding corticosteroids
1
Anti-estrogens
1
Bile acid preparations
1
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Substance Form
Principal Form
170
Salts, Hydrates, Esters, etc.
61
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Search results for
"Pharmacologic Substance[C1909]|Enzyme Inhibitor[C471]|Protein Kinase Inhibitor[C1404]"
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UPADACITINIB
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4RA0KN46E0
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Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
FEDRATINIB
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6L1XP550I6
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CHEMICAL (ACHIRAL)
PEXIDARTINIB
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6783M2LV5X
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CHEMICAL (ACHIRAL)
LAROTRECTINIB
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PF9462I9HX
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CHEMICAL (ABSOLUTE)
ENCORAFENIB
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8L7891MRB6
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CHEMICAL (ABSOLUTE)
GILTERITINIB
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66D92MGC8M
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CHEMICAL (ACHIRAL)
LORLATINIB
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OSP71S83EU
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Class (Stereo):
CHEMICAL (ABSOLUTE)
BARICITINIB
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ISP4442I3Y
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Class (Stereo):
CHEMICAL (ACHIRAL)
FOSTAMATINIB
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SQ8A3S5101
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Class (Stereo):
CHEMICAL (ACHIRAL)
ACALABRUTINIB
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I42748ELQW
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Class (Stereo):
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