TETRACYCLINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H24N2O8
Molecular Weight	444.4346
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TETRACYCLINE

Structure Search

SMILES

[H][C@@]12C[C@@]3([H])C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C

InChI

InChIKey=OFVLGDICTFRJMM-WESIUVDSSA-N

InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H24N2O8
Molecular Weight	444.4346
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:03:23 UTC 2023` Edited by `admin` on `Fri Dec 15 15:03:23 UTC 2023`
Record UNII	F8VB5M810T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TETRACYCLINE

Official Name

English

LYMECYCLINE IMPURITY H [EP IMPURITY]

Common Name

English

PYLERA COMPONENT TETRACYCLINE

Common Name

English

TETRACYCLINE [EP MONOGRAPH]

Common Name

English

(4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

Common Name

English

TETRACYCLINE [ORANGE BOOK]

Common Name

English

TETRACYCLINE [USP IMPURITY]

Common Name

English

TETRACYCLINE [MI]

Common Name

English

TETRACYCLINE COMPONENT OF PYLERA

Common Name

English

TETRACYCLINE [VANDF]

Common Name

English

NSC-108579

Code

English

(4R,4AS,5AS,6S,12AS)-4-(DIMETHYLAMINO)-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE

Systematic Name

English

TETRACYCLINE [MART.]

Common Name

English

TETRACYCLINE [GREEN BOOK]

Common Name

English

TETRACYCLINE [HSDB]

Common Name

English

2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-, (4S-(4.ALPHA.,4A.ALPHA.,5A.ALPHA.,6.BETA.,12A.ALPHA.))-

Common Name

English

OXYTETRACYCLINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Common Name

English

Tetracycline [WHO-DD]

Common Name

English

tetracycline [INN]

Common Name

English

TETRACYCLINE [JAN]

Common Name

English

TETRACYCLINE [USP MONOGRAPH]

Common Name

English

Classification Tree Code System Code

LIVERTOX

NBK547920

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

CFR

21 CFR 520.2345B

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

CFR

21 CFR 520.2345C

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QA02BD02

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

NDF-RT

N0000007948

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QJ51AA07

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QD06AA54

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

S01AA09

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

D06AA04

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

J01AA20

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

CFR

21 CFR 556.720

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

21.1

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QA01AB13

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

J01AA07

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QG51AA02

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QG01AA90

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

NDF-RT

N0000007948

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QS01AA09

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

S03AA02

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

J01RA08

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

NCI_THESAURUS

C1595

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

S02AA08

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

CFR

21 CFR 520.2345E

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

A02BD08

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

CFR

21 CFR 520.2345A

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QG51AG03

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

CFR

21 CFR 520.2345D

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QS02AA08

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

CFR

21 CFR 520.2345

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QD06AA04

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

A01AB13

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

NDF-RT

N0000175505

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QS03AA02

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-ATC

A02BD02

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

WHO-VATC

QJ01AA07

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

Code System Code Type Description

MESH

D013752

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

INN

298

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

ChEMBL

CHEMBL1440

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

FDA UNII

F8VB5M810T

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

SMS_ID

100000082736

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

EVMPD

SUB10942MIG

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

CAS

60-54-8

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

CHEBI

27902

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-481-9

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

DRUG BANK

DB00759

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

DRUG CENTRAL

2611

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

EPA CompTox

DTXSID7023645

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

WIKIPEDIA

TETRACYCLINE

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

NSC

108579

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

DAILYMED

F8VB5M810T

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

RXCUI

10395

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

RxNorm

HSDB

3188

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

CHEBI

77932

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

NCI_THESAURUS

C865

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

MERCK INDEX

m10611

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

Merck Index

LACTMED

Tetracycline

Created by admin on Fri Dec 15 15:03:23 UTC 2023 , Edited by admin on Fri Dec 15 15:03:23 UTC 2023

PRIMARY

Related Record Type Details


					7D3LAT01HT

TETRACYCLINE HEXAHYDRATE

SALT/SOLVATE -> PARENT


					NZ662XY5PP

TETRACYCLINE PHOSPHATE

SALT/SOLVATE -> PARENT

Amount:


					5840721PJZ

OAT-2

TRANSPORTER -> SUBSTRATE

Amount:


					3U6TN9Y2LD

MYCOPLASMA FERMENTANS

TARGET ORGANISM->INHIBITOR

Comments:

18 STRAINS; LESS THE 8 ng/mL for some strains; MIC range listed

Qualification:

MIC90

Amount:


					93V6NC52SB

TETRACYCLINE TRIHYDRATE

SOLVATE->ANHYDROUS


					6B7BK5H33B

TETRACYCLINE PHOSPHATE COMPLEX

SALT/SOLVATE -> PARENT


					7D3LAT01HT

TETRACYCLINE HEXAHYDRATE

SOLVATE->ANHYDROUS


					9ON2SH59JS

TETRACYCLINE CALCIUM

SALT/SOLVATE -> PARENT


					P6R62377KV

TETRACYCLINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:

Related Record Type Details


					KF6I0R5HOO

(4S,4AS,5AS,6S,12AS)-2-ACETYL-4-(DIMETHYLAMINO)-4A,5A,6,12A-TETRAHYDRO-3,6,10,12,12A-PENTAHYDROXY-6-METHYL-1,11(4H,5H)-NAPHTHACENEDIONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					D12GU0X3KA

EPITETRACYCLINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					680VDL31MX

4-EPIANHYDROTETRACYCLINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					7D6EM3S13P

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					X20I9EN955

OXYTETRACYCLINE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					4U7K4N52ZM

OXYTETRACYCLINE HYDROCHLORIDE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					680VDL31MX

4-EPIANHYDROTETRACYCLINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					7284RM98Q5

ANHYDROTETRACYCLINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:


					7284RM98Q5

ANHYDROTETRACYCLINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					D12GU0X3KA

EPITETRACYCLINE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

Related Record Type Details


					F8VB5M810T

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MIC	BIOLOGICAL				SUSCEPTIBILITY: RESISTANT PATHOGEN: ACINETOBACTER spp., ENTEROBACTERIACEAE, S. AUREUS, V. CHOLREAE, Y. PESTIS

MIC	BIOLOGICAL				PATHOGEN: S. PNEUMONIAE, BRUCELLA spp., BACILLUS ANTRHACIS SUSCEPTIBILITY: SUSCEPTIBLE

MIC	BIOLOGICAL				SUSCEPTIBILITY: SUSCEPTIBLE PATHOGEN: H. INFLUENZAE, S. PYOGENES

MIC	BIOLOGICAL				SUSCEPTIBILITY: INTERMEDIATE PATHOGEN: ACINETOBACTER spp., ENTEROBACTERIACEAE, S. AUREUS, V. CHOLREAE, Y. PESTIS

Tmax	PHARMACOKINETIC				ROUTE OF ADMINISTRATION: ORAL

MIC	BIOLOGICAL				PATHOGEN: S. PNEUMONIAE SUSCEPTIBILITY: INTERMEDIATE

MIC	BIOLOGICAL				PATHOGEN: ACINETOBACTER spp., ENTEROBACTERIACEAE, S. AUREUS, V. CHOLREAE, Y. PESTIS SUSCEPTIBILITY: SUSCEPTIBLE

Biological Half-life	PHARMACOKINETIC

MIC	BIOLOGICAL				SUSCEPTIBILITY: INTERMEDIATE PATHOGEN: H. INFLUENZAE S. PYOGENES

MIC	BIOLOGICAL				PATHOGEN: H. INFLUENZAE, S. PYOGENES SUSCEPTIBILITY: RESISTANT