LOSARTAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H23ClN6O
Molecular Weight	422.911
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of LOSARTAN

Structure Search

SMILES

CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C=C2)C3=C(C=CC=C3)C4=NN=NN4

InChI

InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N

InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

HIDE SMILES / InChI

Molecular Formula	C22H23ClN6O
Molecular Weight	422.911
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:44:20 UTC 2023` Edited by `admin` on `Fri Dec 15 15:44:20 UTC 2023`
Record UNII	JMS50MPO89
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LOSARTAN

Official Name

English

NSC-758699

Code

English

ALLISARTAN

Brand Name

English

LOSARTAN [MI]

Common Name

English

LOZAP

Brand Name

English

1H-IMIDAZOLE-5-METHANOL, 2-BUTYL-4-CHLORO-1-((2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL)METHYL)-

Systematic Name

English

ANGIZAAR

Brand Name

English

losartan [INN]

Common Name

English

2-BUTYL-4-CHLORO-1-(P-(O-1H-TETRAZOL-5-YLPHENYL)BENZYL)IMIDAZOLE-5-METHANOL

Common Name

English

HGP1405

Code

English

HGP-1405

Code

English

DUP-89

Common Name

English

LOSARTIC

Brand Name

English

Losartan [WHO-DD]

Common Name

English

LOSARTAN [VANDF]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000000070

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

FDA ORPHAN DRUG

357211

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

LIVERTOX

NBK547842

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

NCI_THESAURUS

C66930

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

WHO-ATC

C09DA01

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

WHO-VATC

QC09DA01

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

NDF-RT

N0000175561

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

WHO-VATC

QC09DB06

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

WHO-ATC

C09CA01

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

FDA ORPHAN DRUG

668618

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

EU-Orphan Drug

EU/3/19/2142

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

WHO-VATC

QC09CA01

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

WHO-ATC

C09DB06

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

Code System Code Type Description

RXCUI

52175

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

RxNorm

FDA UNII

JMS50MPO89

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

HSDB

7043

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

CHEBI

6541

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

CAS

114798-26-4

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

DRUG CENTRAL

1610

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

WIKIPEDIA

LOSARTAN

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

DRUG BANK

DB00678

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

IUPHAR

590

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

ChEMBL

CHEMBL191

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

EVMPD

SUB32953

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

ALTERNATIVE

LACTMED

Losartan

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

EVMPD

SUB08593MIG

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

CHEBI

149504

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

DAILYMED

JMS50MPO89

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

NCI_THESAURUS

C66869

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

NSC

758699

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

EPA CompTox

DTXSID7023227

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

INN

6913

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

SMS_ID

100000082055

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

MERCK INDEX

m6911

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

Merck Index

MESH

D019808

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

PUBCHEM

3961

Created by admin on Fri Dec 15 15:44:21 UTC 2023 , Edited by admin on Fri Dec 15 15:44:21 UTC 2023

PRIMARY

Related Record Type Details


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE


					L9DP834D1P

CYTOCHROME P450 2C9

METABOLIC ENZYME -> SUBSTRATE


					I81U7H57XI

OAT-1

TRANSPORTER -> INHIBITOR


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE


					848C605P1X

CYTOCHROME P450 2J2

METABOLIC ENZYME -> INHIBITOR

Qualification:

IC50

Amount:


					L9DP834D1P

CYTOCHROME P450 2C9

METABOLIC ENZYME -> INHIBITOR

Comments:

Liver concentrations were estimated to be about 50 micromolar. this indicates that Losartan might inhibit the AA metabolism in the liver.

Qualification:

IC50

Amount:


					A9DA3R9ZCK

LOSARTAN HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					LGG1US7EOD

OATL-4

TRANSPORTER -> INHIBITOR


					XYD5147M6H

PEPT-1

TRANSPORTER -> INHIBITOR


					3ST302B24A

LOSARTAN POTASSIUM

SALT/SOLVATE -> PARENT


					4HZ67LW8L7

OAT-4

TRANSPORTER -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					KJ52CU0VV6

LOSARTAN CARBOXALDEHYDE

DERIVATIVE -> PARENT


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR

Related Record Type Details


					4CPU4XV9Z3

1H-IMIDAZOLE-2-PROPANOL, 4-CHLORO-5-(HYDROXYMETHYL)-.ALPHA.-METHYL-1-((2'-(2H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL)METHYL)-

METABOLITE -> PARENT


					GD76OCH73X

EXP-3174

METABOLITE ACTIVE -> PARENT


					G2XDR3BHV9

1H-IMIDAZOLE-5-CARBOXALDEHYDE, 4-CHLORO-2-(1-HYDROXYBUTYL)-1-((2'-(2H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL)METHYL)-

METABOLITE -> PARENT


					YJ2393SFX2

1-(5-(4'-((2-BUTYL-4-CHLORO-5-(HYDROXYMETHYL)-1H-IMIDAZOL-1-YL)METHYL)(1,1'-BIPHENYL)-2-YL)-1H-TETRAZOL-1-YL)-1-DEOXY-.BETA.-D-GLUCOPYRANURONIC ACID

METABOLITE -> PARENT


					MJZ8FR7W5Q

1-(4-CHLORO-5-(HYDROXYMETHYL)-1-((4-(2-(2H-TETRAZOL-5-YL)PHENYL)PHENYL)METHYL)IMIDAZOL-2-YL)BUTAN-1-OL

METABOLITE -> PARENT

Related Record Type Details


					H81CGI9K6Z

BENZYL(METHYL)NITROSAMINE

IMPURITY -> PARENT

Comments:

NMBA is a priority toxic pollutant. FDA is temporarily not objecting to Losartan with NMBA below 9.82 ppm remaining on the market.

Amount:


					3IQ78TTX1A

N-NITROSODIETHYLAMINE

IMPURITY -> PARENT

Comments:

Acceptable intake level of NDEA in ppm.

Amount:


					M43H21IO8R

N-NITROSODIMETHYLAMINE

IMPURITY GENOTOXIC->PARENT

Comments:

NDMA is an organic chemical that is part of a family of potent carcinogens.

Amount:

Related Record Type Details


					JMS50MPO89

LOSARTAN

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC				Elimination PHARMACOKINETIC